nodular regenerative hyperplasia of the liver
Findings
No curated finding names nodular regenerative hyperplasia of the liver yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Nodular regenerative hyperplasia of the liver is a rare parenchymatous liver disease characterized by diffuse benign transformation of the hepatic parenchyma into multiple small nodules (composed of regenerating hepatocytes) and that is usually asymptomatic but can lead to the development of non-cirrhotic portal hypertension and its complications, including esophageal variceal bleeding, hypersplenism and ascites. It is often associated with rheumatologic, autoimmune, hematologic, and myeloproliferative disorders as well as various immune deficiency states and exposure certain drugs and toxins.
Definition from the Mondo Disease Ontology (MONDO:0018835), read 2026-09-29. CC BY 4.0.
Features
2 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormality of the hepatic vasculatureHPOHP:0006707
- Very frequent (80% to 99% of cases)
- Portal hypertensionHPOHP:0001409
- Occasional (5% to 29% of cases)
Where it sits
- A kind of
Other names
1 name
Resolves to: nodular regenerative hyperplasia of the liver
- Also called
- non-cirrhotic nodulation