nodular lymphocyte predominant Hodgkin lymphoma
Findings
No curated finding names nodular lymphocyte predominant Hodgkin lymphoma yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A monoclonal B-cell neoplasm characterized by a nodular, or a nodular and diffuse proliferation of scattered large neoplastic cells known as popcorn or lymphocyte predominant cells (LP cells)- formerly called L&H cells for lymphocytic and/or histiocytic Reed-Sternberg cell variants. The LP cells lack CD15 and CD30 in nearly all instances. Patients are predominantly male, frequently in the 30-50 year age group. Most patients present with limited stage disease (localized peripheral lymphadenopathy, stage I or II). (WHO 2008)
Definition from the Mondo Disease Ontology (MONDO:0044778), read 2026-09-29. CC BY 4.0.
Features
14 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- ImmunodeficiencyHPOHP:0002721
- Very frequent (80% to 99% of cases)
- LymphadenopathyHPOHP:0002716
- Very frequent (80% to 99% of cases)
- LymphomaHPOHP:0002665
- Very frequent (80% to 99% of cases)
- FeverHPOHP:0001945
- Frequent (30% to 79% of cases)
- Abnormal bone marrow cell morphologyHPOHP:0005561
- Occasional (5% to 29% of cases)
- AnorexiaHPOHP:0002039
- Occasional (5% to 29% of cases)
- B-cell lymphoma
Show the remaining 2
- SplenomegalyHPOHP:0001744
- Occasional (5% to 29% of cases)
- Weight lossHPOHP:0001824
- Occasional (5% to 29% of cases)
Where it sits
- A kind of
- Narrower terms (1)
Other names
5 names
Resolves to: nodular lymphocyte predominant Hodgkin lymphoma
- Also called
- Hodgkin lymphoma nodular LP, NOSHodgkin lymphoma nodular lymphocyte predominant type, NOSNLPHLnodular lymphocyte predominant Hodgkin's lymphomanodular lymphocyte-predominant Hodgkin lymphoma