new-onset refractory status epilepticus
Findings
No curated finding names new-onset refractory status epilepticus yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
New-onset refractory status epilepticus is an acute encephalopathy with inflammation-mediated status epilepticus characterized by an acute refractory status epilepticus, typically of the tonic-clonic type, following prodromal symptoms of confusion, fever, fatigue, headache, symptoms of gastrointestinal or upper respiratory tract infection, behavioral changes or hallucinations. Brain MRI abnormalities and abnormal findings in CSF, including pleocytosis and/or elevated protein levels, are frequently found during acute episode. Treatment-resistant epilepsy, cognitive and psychiatric impairments are usual consequences.
Definition from the Mondo Disease Ontology (MONDO:0018199), read 2026-09-29. CC BY 4.0.
Features
37 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Status epilepticusHPOHP:0002133
- Obligate (100% of cases)
- Interictal EEG abnormalityHPOHP:0025373
- Very frequent (80% to 99% of cases)
- Refractory status epilepticusHPOHP:0032867
- Very frequent (80% to 99% of cases)
- Seizure precipitated by febrile infectionHPOHP:0032894
- Very frequent (80% to 99% of cases)
- Abnormal circulating interleukin concentrationHPOHP:0011117
- Frequent (30% to 79% of cases)
- Abnormal head movementsHPOHP:0002457
- Frequent (30% to 79% of cases)
Show the remaining 25
- EEG with generalized slow activityHPOHP:0010845
- Frequent (30% to 79% of cases)
- EEG with temporal epileptiform dischargesHPOHP:0033717
- Frequent (30% to 79% of cases)
- Facial ticsHPOHP:0011468
- Frequent (30% to 79% of cases)
- FeverHPOHP:0001945
- Frequent (30% to 79% of cases)
- Focal autonomic seizureHPOHP:0011154
- Frequent (30% to 79% of cases)
- Focal aware motor seizureHPOHP:0020217
- Frequent (30% to 79% of cases)
Where it sits
- A kind of
Other names
1 name
Resolves to: new-onset refractory status epilepticus
- Also called
- NORSE