neuronopathy, distal hereditary motor, autosomal dominant 15
MONDO:0976226Mondo
Findings
No curated finding names neuronopathy, distal hereditary motor, autosomal dominant 15 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
- Inheritance
- Autosomal dominant inheritance
- Onset and course
- Middle age onset
HPO, annotations 2026-09-02
Features
23 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Decreased Achilles reflexHPOHP:0009072
- 1 of 1 reported patient
- Distal lower limb amyotrophyHPOHP:0008944
- 7 of 8 reported patients
- Distal lower limb muscle weaknessHPOHP:0009053
- 7 of 8 reported patients
- Absent Achilles reflexHPOHP:0003438
- 6 of 7 reported patients
- EMG: neuropathic changesHPOHP:0003445
- 6 of 7 reported patients
- Foot dorsiflexor weaknessHPOHP:0009027
- 6 of 8 reported patients
- Decreased compound muscle action potential amplitudeHPOHP:0033383
- 5 of 7 reported patients
- Angulated muscle fibersHPOHP:0034045
- 2 of 3 reported patients
- Elevated circulating creatine kinase activityHPOHP:0003236
- 4 of 6 reported patients
- Fiber type groupingHPOHP:0033685
- 2 of 3 reported patients
- Muscle fiber atrophyHPOHP:0100295
- 2 of 3 reported patients
- Decreased patellar reflexHPOHP:0011808
- 2 of 6 reported patients
Show the remaining 11
- Left ventricular hypertrophyHPOHP:0001712
- 2 of 6 reported patients
- Absent patellar reflexesHPOHP:0006844
- 2 of 8 reported patients
- Muscle spasmHPOHP:0003394
- 1 of 5 reported patients
- Abnormal exteroceptive sensationHPOHP:0033747
- 0 of 7 reported patients
- Abnormal sensory nerve conduction velocityHPOHP:0040132
- 0 of 7 reported patients
- Distal upper limb muscle weaknessHPOHP:0008959
- 0 of 8 reported patients