neuromyelitis optica
Findings
No curated finding names neuromyelitis optica yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A rare inflammatory disease of the central nervous system characterized mainly by attacks of uni- or bilateral optic neuritis (ON) and acute myelitis.
Definition from the Mondo Disease Ontology (MONDO:0019100), read 2026-09-29. CC BY 4.0.
Features
17 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Autoimmune antibody positivityHPOHP:0030057
- Very frequent (80% to 99% of cases)
- Functional abnormality of the bladderHPOHP:0000009
- Very frequent (80% to 99% of cases)
- MyelitisHPOHP:0012486
- Very frequent (80% to 99% of cases)
- Neuronal loss in central nervous systemHPOHP:0002529
- Very frequent (80% to 99% of cases)
- Ocular painHPOHP:0200026
- Very frequent (80% to 99% of cases)
- Optic neuritisHPOHP:0100653
- Very frequent (80% to 99% of cases)
- ParaplegiaHPOHP:0010550
- Very frequent (80% to 99% of cases)
- Peripheral demyelinationHPOHP:0011096
- Very frequent (80% to 99% of cases)
- Somatic sensory dysfunctionHPOHP:0003474
- Very frequent (80% to 99% of cases)
- Visual lossHPOHP:0000572
- Very frequent (80% to 99% of cases)
- Abnormal brain morphologyHPOHP:0012443
- Frequent (30% to 79% of cases)
- Anti-aquaporin 4 antibody positivityHPOHP:0033342
- Frequent (30% to 79% of cases)
Show the remaining 5
- Anti-myelin oligodendrocyte glycoprotein antibody positivityHPOHP:0032492
- Occasional (5% to 29% of cases)
- CSF pleocytosisHPOHP:0012229
- Occasional (5% to 29% of cases)
- NauseaHPOHP:0002018
- Occasional (5% to 29% of cases)
- Recurrent singultusHPOHP:0100247
- Occasional (5% to 29% of cases)
- Respiratory failureHPOHP:0002878
- Occasional (5% to 29% of cases)
Genes
4 genes
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
Where it sits
Other names
2 names
Resolves to: neuromyelitis optica
- Also called
- Devic diseaseNeuromyelitis Optica Spectrum Disorder