neuroleptic malignant syndrome
MONDO:0019790Mondo
Findings
No curated finding names neuroleptic malignant syndrome yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Neuroleptic malignant syndrome (NMS) is an idiosyncratic condition associated with administration of antipsychotic and other central dopaminergic blockers, and characterized by hyperthermia, muscular rigidity, autonomic dysfunction and altered consciousness.
Definition from the Mondo Disease Ontology (MONDO:0019790), read 2026-09-29. CC BY 4.0.
Features
54 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormal autonomic nervous system physiologyHPOHP:0012332
- Very frequent (80% to 99% of cases)
- Extrapyramidal muscular rigidityHPOHP:0007076
- Very frequent (80% to 99% of cases)
- FeverHPOHP:0001945
- Very frequent (80% to 99% of cases)
- HyperhidrosisHPOHP:0000975
- Very frequent (80% to 99% of cases)
- MutismHPOHP:0002300
- Very frequent (80% to 99% of cases)
- Reduced consciousnessHPOHP:0004372
- Very frequent (80% to 99% of cases)
- DroolingHPOHP:0002307
- Frequent (30% to 79% of cases)
- DysphagiaHPOHP:0002015
- Frequent (30% to 79% of cases)
- Elevated circulating creatine kinase activityHPOHP:0003236
- Frequent (30% to 79% of cases)
- Excessive salivationHPOHP:0003781
- Frequent (30% to 79% of cases)
- FatigueHPOHP:0012378
- Frequent (30% to 79% of cases)
- HypertensionHPOHP:0000822
- Frequent (30% to 79% of cases)
Show the remaining 42
- Increased total leukocyte countHPOHP:0001974
- Frequent (30% to 79% of cases)
- Metabolic acidosisHPOHP:0001942
- Frequent (30% to 79% of cases)
- Muscle spasmHPOHP:0003394
- Frequent (30% to 79% of cases)
- TachycardiaHPOHP:0001649
- Frequent (30% to 79% of cases)
- TremorHPOHP:0001337
- Frequent (30% to 79% of cases)
- Acute kidney injuryHPOHP:0001919
- Occasional (5% to 29% of cases)
Where it sits
Other names
1 name
Resolves to: neuroleptic malignant syndrome
- Also called
- NMS