neurofibroma
Findings
No curated finding names neurofibroma yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
An intraneural or extraneural neoplasm arising from nerve tissues and neural sheaths. It is composed of perineurial-like fibroblasts and Schwann cells. It usually presents as a localized cutaneous lesion and less often as a circumscribed peripheral nerve mass. Patients with neurofibromatosis type 1 present with multiple masses. Neurofibromas which arise from major nerves and plexiform neurofibromas are precursor lesions to malignant peripheral nerve sheath tumors.
Definition from the Mondo Disease Ontology (MONDO:0016755), read 2026-09-29. CC BY 4.0.
Features
26 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- NeurofibromaHPOHP:0001067
- Obligate (100% of cases)
- Enlarged peripheral nerveHPOHP:0012645
- Frequent (30% to 79% of cases)
- Periarticular subcutaneous nodulesHPOHP:0007470
- Frequent (30% to 79% of cases)
- Plexiform neurofibromaHPOHP:0009732
- Frequent (30% to 79% of cases)
- Subcutaneous neurofibromaHPOHP:0100698
- Frequent (30% to 79% of cases)
- Abnormal cranial nerve morphologyHPOHP:0001291
- Occasional (5% to 29% of cases)
- Paraspinal neurofibroma
Show the remaining 14
- Atypical neurofibromatosisHPOHP:0007524
- Very rare (1% to 4% of cases)
- Enlargement of parotid glandHPOHP:0011801
- Very rare (1% to 4% of cases)
- Facial neoplasmHPOHP:0012289
- Very rare (1% to 4% of cases)
- Intestinal bleedingHPOHP:0002584
- Very rare (1% to 4% of cases)
- KyphoscoliosisHPOHP:0002751
- Very rare (1% to 4% of cases)
- MacrocephalyHPOHP:0000256
- Very rare (1% to 4% of cases)
Where it sits
Other names
2 names
Resolves to: neurofibroma
- Also called
- neurofibroma (WHO grade I)neurofibroma, benign