neonatal lupus erythematosus
Findings
No curated finding names neonatal lupus erythematosus yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A self-limited skin rash that appears in the neonatal period and usually resolves in four to six months after birth. It is caused by placental transfer of maternal autoantibodies, usually anti-Ro antibody. In a minority of cases, it is associated with congenital heart block, hepatitis, or thrombocytopenia. The mothers of the affected babies may be asymptomatic or suffer from systemic lupus erythematosus, Sjogren's syndrome, or rheumatoid arthritis.
Definition from the Mondo Disease Ontology (MONDO:0018360), read 2026-09-29. CC BY 4.0.
Features
35 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Autoimmune antibody positivityHPOHP:0030057
- Very frequent (80% to 99% of cases)
- Abnormality of blood and blood-forming tissuesHPOHP:0001871
- Frequent (30% to 79% of cases)
- Abnormality of the liverHPOHP:0001392
- Frequent (30% to 79% of cases)
- Abnormality of the skinHPOHP:0000951
- Frequent (30% to 79% of cases)
- Abnormal cerebral white matter morphologyHPOHP:0002500
- Occasional (5% to 29% of cases)
- AnemiaHPOHP:0001903
- Occasional (5% to 29% of cases)
Show the remaining 23
- Erythematous plaqueHPOHP:0025474
- Occasional (5% to 29% of cases)
- Heart blockHPOHP:0012722
- Occasional (5% to 29% of cases)
- HepatomegalyHPOHP:0002240
- Occasional (5% to 29% of cases)
- HydrocephalusHPOHP:0000238
- Occasional (5% to 29% of cases)
- HyperkeratosisHPOHP:0000962
- Occasional (5% to 29% of cases)
- Maculopapular exanthemaHPOHP:0040186
- Occasional (5% to 29% of cases)
Where it sits
Other names
1 name
Resolves to: neonatal lupus erythematosus
- Also called
- Neonatal Lupus