neonatal alloimmune neutropenia
Findings
No curated finding names neonatal alloimmune neutropenia yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A rare acquired neutropenia characterized by isolated neutropenia in a newborn due to maternal alloimmunization against human neutrophil antigens (HNA) inherited from the father and present on fetal neutrophils, and subsequent increased breakdown of the latter. The condition is self-limiting and resolves after several weeks. It usually presents with only mild bacterial infections or may even be asymptomatic, although severe forms with sepsis and fatal outcome have also been reported.
Definition from the Mondo Disease Ontology (MONDO:0018739), read 2026-09-29. CC BY 4.0.
- Onset and course
- Miscarriage
HPO, annotations 2026-09-02
Features
10 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Antineutrophil antibody positivityHPOHP:0003453
- Very frequent (80% to 99% of cases)
- Autoimmune neutropeniaHPOHP:0001904
- Very frequent (80% to 99% of cases)
- PneumoniaHPOHP:0002090
- Frequent (30% to 79% of cases)
- Severe infectionHPOHP:0032169
- Frequent (30% to 79% of cases)
- FeverHPOHP:0001945
- Occasional (5% to 29% of cases)
- JaundiceHPOHP:0000952
- Occasional (5% to 29% of cases)
- MeningitisHPO
Where it sits
- A kind of