Nelson syndrome
MONDO:0016035Mondo
Findings
No curated finding names Nelson syndrome yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A syndrome that develops following bilateral adrenalectomy for Cushing syndrome. The signs and symptoms result from the presence of an adenocorticotropin-secreting pituitary gland adenoma, and include enlargement of the sella turcica and pressure on the adjacent structures, and skin hyperpigmentation.
Definition from the Mondo Disease Ontology (MONDO:0016035), read 2026-09-29. CC BY 4.0.
Features
27 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Adrenocorticotropic hormone excessHPOHP:0011749
- Obligate (100% of cases)
- Secondary hypercortisolismHPOHP:0011744
- Obligate (100% of cases)
- Increased circulating cortisol levelHPOHP:0003118
- Very frequent (80% to 99% of cases)
- Increased urinary cortisol levelHPOHP:0012030
- Very frequent (80% to 99% of cases)
- Pituitary corticotropic cell adenomaHPOHP:0008291
- Very frequent (80% to 99% of cases)
- Abnormal kinetic perimetry testHPOHP:0030591
- Frequent (30% to 79% of cases)
- Bitemporal hemianopiaHPOHP:0030521
- Frequent (30% to 79% of cases)
- Generalized hyperpigmentationHPOHP:0007440
- Frequent (30% to 79% of cases)
- HypertensionHPOHP:0000822
- Frequent (30% to 79% of cases)
- HypokalemiaHPOHP:0002900
- Frequent (30% to 79% of cases)
- Lower limb muscle weaknessHPOHP:0007340
- Frequent (30% to 79% of cases)
- Slow decrease in visual acuityHPOHP:0007924
- Frequent (30% to 79% of cases)
Show the remaining 15
- Striae distensaeHPOHP:0001065
- Frequent (30% to 79% of cases)
- Type II diabetes mellitusHPOHP:0005978
- Frequent (30% to 79% of cases)
- Visual impairmentHPOHP:0000505
- Frequent (30% to 79% of cases)
- Anterior hypopituitarismHPOHP:0000830
- Occasional (5% to 29% of cases)
- Increased intracranial pressureHPOHP:0002516
- Occasional (5% to 29% of cases)
- Oculomotor nerve palsyHPOHP:0012246
- Occasional (5% to 29% of cases)
Where it sits
- A kind of
Other names
1 name
Resolves to: Nelson syndrome
- Also called
- Nelson's syndrome