myeloid neoplasm associated with PDGFRA rearrangement
Findings
No curated finding names myeloid neoplasm associated with PDGFRA rearrangement yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A rare, malignant, neoplastic disease characterized by clonal proliferation of myeloid and/or lymphoid precursors harboring rearrangements in the PDGFRA gene, in the blood, bone marrow and often other tissues as well (spleen, lymph nodes, skin, etc.). It usually presents as chronic eosinophilic leukemia or, less commonly, as acute myeloid leukemia or T-lymphoblastic leukemia with eosinophilia. Patients usually present with eosinophilia, anemia, thrombocytopenia, neutrophilia, splenomegaly, lymphadenopathy, fever, sweating and/or weight loss. Tissue infiltration by eosinophils can manifest with skin rash, erythema, cough, neurological alterations, gastrointestinal symptoms or, rarely, endomyocardial fibrosis and restrictive cardiomyopathy.
Definition from the Mondo Disease Ontology (MONDO:0015689), read 2026-09-29. CC BY 4.0.
Where it sits
Other names
3 names
Resolves to: myeloid neoplasm associated with PDGFRA rearrangement
- Also called
- myeloid and lymphoid neoplasms associated with PDGFRA rearrangementmyeloid and lymphoid neoplasms with PDGFRA rearrangementmyeloid/lymphoid neoplasms with PDGFRA rearrangement