myalgia-eosinophilia syndrome associated with tryptophan
Findings
No curated finding names myalgia-eosinophilia syndrome associated with tryptophan yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A rare systemic disease characterized by severe myalgia and peripheral eosinophilia associated with tryptophan dietary supplementation. The symptoms do not subside after tryptophan discontinuation. Clinical presentation includes muscle tenderness and cramps, fatigue, weakness, paresthesia, peripheral edema, arthralgia, dyspnea, skin rash, dry mouth, and development of scleroderma-like skin abnormalities.
Definition from the Mondo Disease Ontology (MONDO:0016822), read 2026-09-29. CC BY 4.0.
Features
10 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormality of the musculatureHPOHP:0003011
- Very frequent (80% to 99% of cases)
- Flat occiputHPOHP:0005469
- Very frequent (80% to 99% of cases)
- Increased total eosinophil countHPOHP:0001880
- Very frequent (80% to 99% of cases)
- Abnormal pleura morphologyHPOHP:0002103
- Frequent (30% to 79% of cases)
- ArthritisHPOHP:0001369
- Frequent (30% to 79% of cases)
- Decreased total lymphocyte countHPOHP:0001888
- Frequent (30% to 79% of cases)
Where it sits
- A kind of