multiple endocrine neoplasia type 2
Findings
No curated finding names multiple endocrine neoplasia type 2 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Multiple endocrine neoplasia type 2 (MEN2) is a multiple endocrine neoplasia, a polyglandular cancer syndrome characterized by the occurrence of medullary thyroid carcinoma (MTC), pheochromocytoma (PCC), in one variant, primary hyperparathyroidism (PHPT). There are three forms: MEN2A, MEN2B, and familial medullary thyroid carcinoma (FMTC).
Definition from the Mondo Disease Ontology (MONDO:0019003), read 2026-09-29. CC BY 4.0.
Features
48 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Medullary thyroid carcinomaHPOHP:0002865
- Very frequent (80% to 99% of cases)
- AnxietyHPOHP:0000739
- Frequent (30% to 79% of cases)
- Cervical neoplasmHPOHP:0032241
- Frequent (30% to 79% of cases)
- DiarrheaHPOHP:0002014
- Frequent (30% to 79% of cases)
- Elevated circulating calcitonin concentrationHPOHP:0003528
- Frequent (30% to 79% of cases)
- Elevated urinary catecholamine levelHPOHP:0011976
- Frequent (30% to 79% of cases)
- Elevated urinary epinephrine level
Show the remaining 36
- Hypertensive crisisHPOHP:0100735
- Frequent (30% to 79% of cases)
- PallorHPOHP:0000980
- Frequent (30% to 79% of cases)
- PalpitationsHPOHP:0001962
- Frequent (30% to 79% of cases)
- Parathyroid hyperplasiaHPOHP:0008208
- Frequent (30% to 79% of cases)
- PheochromocytomaHPOHP:0002666
- Frequent (30% to 79% of cases)
- Thyroid C cell hyperplasiaHPOHP:0011781
- Frequent (30% to 79% of cases)
Where it sits
Other names
1 name
Resolves to: multiple endocrine neoplasia type 2
- Also called
- MEN2