multifocal motor neuropathy
MONDO:0018979Mondo
Findings
No curated finding names multifocal motor neuropathy yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Multifocal motor neuropathy (MMN) is a rare acquired immune-mediatedneuropathy characterized clinically by a purely motor deficit with conduction block and asymmetric multifocal weakness, fasciculations, and cramping.
Definition from the Mondo Disease Ontology (MONDO:0018979), read 2026-09-29. CC BY 4.0.
Features
12 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Progressive distal muscle weaknessHPOHP:0009063
- Very frequent (80% to 99% of cases)
- Diminished deep tendon reflexHPOHP:0001315
- Frequent (30% to 79% of cases)
- FasciculationsHPOHP:0002380
- Frequent (30% to 79% of cases)
- Functional motor deficitHPOHP:0004302
- Frequent (30% to 79% of cases)
- Ganglioside accumulationHPOHP:0004345
- Frequent (30% to 79% of cases)
- Increased CSF protein concentrationHPOHP:0002922
- Frequent (30% to 79% of cases)
- Limb muscle weaknessHPOHP:0003690
- Frequent (30% to 79% of cases)
- Limited wrist extensionHPOHP:0006251
- Frequent (30% to 79% of cases)
- Motor conduction blockHPOHP:0012078
- Frequent (30% to 79% of cases)
- Muscle spasmHPOHP:0003394
- Frequent (30% to 79% of cases)
- Progressive muscle weaknessHPOHP:0003323
- Frequent (30% to 79% of cases)
- Weakness of long finger extensor musclesHPOHP:0009077
- Frequent (30% to 79% of cases)
Where it sits
- A kind of
Other names
3 names
Resolves to: multifocal motor neuropathy
- Also called
- MMNMMNCBmultifocal motor neuropathy with conduction block