multicentric osteolysis-nodulosis-arthropathy spectrum
Findings
No curated finding names multicentric osteolysis-nodulosis-arthropathy spectrum yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A rare genetic chronic skeletal disorder characterized by peripheral osteolysis (especially carpal and tarsal bones), interphalangeal joint erosions, subcutaneous fibrocollagenous nodules, facial dysmorphism, and a wide range of associated manifestations.
Definition from the Mondo Disease Ontology (MONDO:0018298), read 2026-09-29. CC BY 4.0.
Features
39 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormal facial shapeHPOHP:0001999
- Very frequent (80% to 99% of cases)
- Abnormal hand morphologyHPOHP:0005922
- Very frequent (80% to 99% of cases)
- ArthritisHPOHP:0001369
- Very frequent (80% to 99% of cases)
- ArthropathyHPOHP:0003040
- Very frequent (80% to 99% of cases)
- Carpal osteolysisHPOHP:0001495
- Very frequent (80% to 99% of cases)
- HirsutismHPOHP:0001007
- Very frequent (80% to 99% of cases)
- OsteolysisHPOHP:0002797
- Very frequent (80% to 99% of cases)
- Osteolysis involving bones of the lower limbsHPOHP:0009139
- Very frequent (80% to 99% of cases)
- Osteolysis involving bones of the upper limbsHPOHP:0045039
- Very frequent (80% to 99% of cases)
- Osteolysis involving tarsal bonesHPOHP:0006234
- Very frequent (80% to 99% of cases)
- OsteopeniaHPOHP:0000938
- Very frequent (80% to 99% of cases)
- OsteoporosisHPOHP:0000939
- Very frequent (80% to 99% of cases)
Show the remaining 27
- Abnormal vertebral body morphologyHPOHP:0003312
- Frequent (30% to 79% of cases)
- Abnormality of the cardiovascular systemHPOHP:0001626
- Frequent (30% to 79% of cases)
- BrachycephalyHPOHP:0000248
- Frequent (30% to 79% of cases)
- Broad clavicleHPOHP:0000916
- Frequent (30% to 79% of cases)
- Broad metacarpalsHPOHP:0001230
- Frequent (30% to 79% of cases)
- Localized skin lesionHPOHP:0011355
- Frequent (30% to 79% of cases)
Genes
2 genes
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
Where it sits
- A kind of
- Narrower terms (2)
Other names
1 name
Resolves to: multicentric osteolysis-nodulosis-arthropathy spectrum
- Also called
- MONA spectrum