mu-heavy chain disease
MONDO:0015044Mondo
Findings
No curated finding names mu-heavy chain disease yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Mu-heavy chain disease (mu-HCD) is a type of HCD characterized by the production of incomplete monoclonal mu-heavy chains without associated light chains. The clinical presentation resembles that of patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL).
Definition from the Mondo Disease Ontology (MONDO:0015044), read 2026-09-29. CC BY 4.0.
Features
13 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormal bone marrow cell morphologyHPOHP:0005561
- Very frequent (80% to 99% of cases)
- Abnormal total B cell countHPOHP:0010975
- Very frequent (80% to 99% of cases)
- Increased circulating immunoglobulin concentrationHPOHP:0010702
- Very frequent (80% to 99% of cases)
- SplenomegalyHPOHP:0001744
- Very frequent (80% to 99% of cases)
- AnemiaHPOHP:0001903
- Frequent (30% to 79% of cases)
- Bence Jones ProteinuriaHPOHP:0030156
- Frequent (30% to 79% of cases)
- FeverHPOHP:0001945
- Frequent (30% to 79% of cases)
- HepatomegalyHPOHP:0002240
- Frequent (30% to 79% of cases)
- LymphadenopathyHPOHP:0002716
- Frequent (30% to 79% of cases)
- Weight lossHPOHP:0001824
- Frequent (30% to 79% of cases)
- NephropathyHPOHP:0000112
- Occasional (5% to 29% of cases)
- OsteolysisHPOHP:0002797
- Occasional (5% to 29% of cases)
Show the remaining 1
- OsteoporosisHPOHP:0000939
- Occasional (5% to 29% of cases)
Where it sits
- A kind of
Other names
3 names
Resolves to: mu-heavy chain disease
- Also called
- mu chain diseasemu heavy chain diseasemu-HCD