Morgagni-Stewart-Morel syndrome
Findings
No curated finding names Morgagni-Stewart-Morel syndrome yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Morgagni-Stewart-Morel syndrome is characterized by thickening of the inner table of the frontal bone, sometimes associated with obesity and hypertrichosis. It mainly affects women over 35 years of age. The prevalence and clinical significance of hyperostosis frontalis interna is unknown. Transmission is either X-linked or autosomal dominant.
Definition from the Mondo Disease Ontology (MONDO:0007766), read 2026-09-29. CC BY 4.0.
Features
30 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Hyperostosis frontalis internaHPOHP:0004438
- Obligate (100% of cases)
- Abnormal metabolismHPOHP:0032245
- Very frequent (80% to 99% of cases)
- Abnormality of the endocrine systemHPOHP:0000818
- Very frequent (80% to 99% of cases)
- Abnormality of the nervous systemHPOHP:0000707
- Very frequent (80% to 99% of cases)
- Atypical behaviorHPOHP:0000708
- Very frequent (80% to 99% of cases)
- HeadacheHPOHP:0002315
- Very frequent (80% to 99% of cases)
- Obesity
Show the remaining 18
- AcneHPOHP:0001061
- Occasional (5% to 29% of cases)
- Action tremorHPOHP:0002345
- Occasional (5% to 29% of cases)
- Brain atrophyHPOHP:0012444
- Occasional (5% to 29% of cases)
- Brisk reflexesHPOHP:0001348
- Occasional (5% to 29% of cases)
- Cognitive impairmentHPOHP:0100543
- Occasional (5% to 29% of cases)
- DepressionHPOHP:0000716
- Occasional (5% to 29% of cases)
Where it sits
Other names
1 name
Resolves to: Morgagni-Stewart-Morel syndrome
- Also called
- Hyperostosis Frontalis Interna