moderately severe hemophilia A
Findings
No curated finding names moderately severe hemophilia A yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Moderately severe hemophilia A is a form of hemophilia A characterized by factor VIII deficiency leading to abnormal bleeding as a result of minor injuries, or following surgery or tooth extraction.
Definition from the Mondo Disease Ontology (MONDO:0015720), read 2026-09-29. CC BY 4.0.
Features
26 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormal bleedingHPOHP:0001892
- Very frequent (80% to 99% of cases)
- Prolonged partial thromboplastin timeHPOHP:0003645
- Very frequent (80% to 99% of cases)
- Reduced factor VIII activityHPOHP:0003125
- Very frequent (80% to 99% of cases)
- ArthralgiaHPOHP:0002829
- Frequent (30% to 79% of cases)
- Bleeding with minor or no traumaHPOHP:0011889
- Frequent (30% to 79% of cases)
- Gingival bleedingHPOHP:0000225
- Frequent (30% to 79% of cases)
- Intramuscular hematomaHPOHP:0012233
- Frequent (30% to 79% of cases)
- Joint hemorrhageHPOHP:0005261
- Frequent (30% to 79% of cases)
- Subcutaneous hemorrhageHPOHP:0001933
- Frequent (30% to 79% of cases)
- ArthropathyHPOHP:0003040
- Occasional (5% to 29% of cases)
- Cartilage destructionHPOHP:0100773
- Occasional (5% to 29% of cases)
- Gastrointestinal hemorrhageHPOHP:0002239
- Occasional (5% to 29% of cases)
Show the remaining 14
- HeadacheHPOHP:0002315
- Occasional (5% to 29% of cases)
- HematuriaHPOHP:0000790
- Occasional (5% to 29% of cases)
- Intracranial hemorrhageHPOHP:0002170
- Occasional (5% to 29% of cases)
- Joint swellingHPOHP:0001386
- Occasional (5% to 29% of cases)
- Limitation of joint mobilityHPOHP:0001376
- Occasional (5% to 29% of cases)
- Prolonged bleeding after dental extractionHPOHP:0006298
- Occasional (5% to 29% of cases)
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- F8HGNC:3546
- Supportive · Orphanet · X-linked · 2021
Where it sits
- A kind of
Other names
3 names
Resolves to: moderately severe hemophilia A
- Also called
- moderately severe factor VIII deficiencymoderately severe haemophilia type Amoderately severe hemophilia type A