migraine, familial hemiplegic, 2
Findings
No curated finding names migraine, familial hemiplegic, 2 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Any familial or sporadic hemiplegic migraine in which the cause of the disease is a mutation in the ATP1A2 gene.
Definition from the Mondo Disease Ontology (MONDO:0011232), read 2026-09-29. CC BY 4.0.
- Inheritance
- Autosomal dominant inheritance
- Onset and course
- Juvenile onset · Young adult onset
HPO, annotations 2026-09-02
Features
16 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- HemiparesisHPOHP:0001269
- 8 of 8 reported patients
- MigraineHPOHP:0002076
- 8 of 8 reported patients
- NauseaHPOHP:0002018
- 8 of 8 reported patients
- ConfusionHPOHP:0001289
- 7 of 8 reported patients
- ComaHPOHP:0001259
- 6 of 8 reported patients
- FeverHPOHP:0001945
- 5 of 8 reported patients
- Bilateral tonic-clonic seizureHPOHP:0002069
Show the remaining 4
- Gait ataxiaHPOHP:0002066
- 1 of 8 reported patients
- NystagmusHPOHP:0000639
- 1 of 8 reported patients
- TremorHPOHP:0001337
- 1 of 8 reported patients
- Intellectual disabilityHPOHP:0001249
- 0 of 8 reported patients
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- ATP1A2HGNC:800
- Definitive · Ambry Genetics · Autosomal dominant · 2017
- Definitive · G2P · Autosomal dominant · 2025
- Strong · Genomics England PanelApp · Autosomal dominant · 2021
- Strong · Labcorp Genetics (formerly Invitae) · Autosomal dominant · 2023
- Strong · PanelApp Australia · Autosomal dominant · 2025
Where it sits
- A kind of
Other names
3 names
Resolves to: migraine, familial hemiplegic, 2
- Also called
- ATP1A2 familial or sporadic hemiplegic migrainefamilial or sporadic hemiplegic migraine caused by mutation in ATP1A2migraine, familial hemiplegic, type 2