Melkersson-Rosenthal syndrome
Findings
No curated finding names Melkersson-Rosenthal syndrome yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
The Melkersson-Rosenthal syndrome is a rare disorder characterized by a triad of recurrent orofacial swelling, relapsing facial paralysis and fissured tongue and onset in childhood or early adolescence. It has an estimated incidence of 8/10,000. The etiology is unknown but hereditary predisposition is suspected.
Definition from the Mondo Disease Ontology (MONDO:0007969), read 2026-09-29. CC BY 4.0.
Features
14 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- CheilitisHPOHP:0100825
- Very frequent (80% to 99% of cases)
- Cranial nerve paralysisHPOHP:0006824
- Very frequent (80% to 99% of cases)
- EdemaHPOHP:0000969
- Very frequent (80% to 99% of cases)
- Inflammatory abnormality of the skinHPOHP:0011123
- Very frequent (80% to 99% of cases)
- Mask-like faciesHPOHP:0000298
- Very frequent (80% to 99% of cases)
- OligosacchariduriaHPOHP:0010471
- Very frequent (80% to 99% of cases)
- Periorbital edemaHPOHP:0100539
- Very frequent (80% to 99% of cases)
- Facial palsyHPOHP:0010628
- Frequent (30% to 79% of cases)
- Furrowed tongueHPOHP:0000221
- Frequent (30% to 79% of cases)
- MacroglossiaHPOHP:0000158
- Frequent (30% to 79% of cases)
- Abnormal autonomic nervous system physiologyHPOHP:0012332
- Occasional (5% to 29% of cases)
- FeverHPOHP:0001945
- Occasional (5% to 29% of cases)
Show the remaining 2
- LymphadenopathyHPOHP:0002716
- Occasional (5% to 29% of cases)
- NystagmusHPOHP:0000639
- Occasional (5% to 29% of cases)
Where it sits
Other names
1 name
Resolves to: Melkersson-Rosenthal syndrome
- Also called
- Melkersson's syndrome