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CompoundsSubstances with curated findings
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ReactionsRhea and Human-GEM, by subsystem
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Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
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Articles

Chemistry

Reactions
Reach

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Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

Disease

melancholia

MONDO:0002444Mondo

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Findings

No curated finding names melancholia yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.

Definition

A subtype of depression characterized by the inability to find pleasure in positive things combined with physical agitation, insomnia, or decreased appetite.

Definition from the Mondo Disease Ontology (MONDO:0002444), read 2026-09-29. CC BY 4.0.

Where it sits

A kind of: depressive disorder

Other names

2 names

Resolves to: melancholia

Also called: depression with melancholic featuresmelancholic depression