maturity-onset diabetes of the young type 2
Findings
No curated finding names maturity-onset diabetes of the young type 2 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Monogenic diabetes caused by inactivating mutation(s) in the GCK gene, encoding glucokinase. Heterozygous GCK mutations may manifest as mild hyperglycemia, which is not progressive, and usually requires no treatment. Homozygous GCK mutations result in permanent neonatal diabetes.
Definition from the Mondo Disease Ontology (MONDO:0007453), read 2026-09-29. CC BY 4.0.
- Inheritance
- Autosomal dominant inheritance
- Onset and course
- Juvenile onset
HPO, annotations 2026-09-02
Features
1 feature
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Maturity-onset diabetes of the youngHPOHP:0004904
- 16 of 16 reported patients
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- GCKHGNC:4195
- Definitive · Ambry Genetics · Autosomal dominant · 2018
- Strong · Genomics England PanelApp · Autosomal dominant · 2020
- Strong · Labcorp Genetics (formerly Invitae) · Autosomal dominant · 2023
- Strong · PanelApp Australia · Autosomal dominant · 2025
Where it sits
- A kind of
Other names
8 names
Resolves to: maturity-onset diabetes of the young type 2
- Also called
- GCK maturity-onset diabetes of the young (disease)GCK-associated diabetes mellitusglucokinase-associated diabetes mellitusmaturity onset diabetes of the Young, type 2maturity-onset diabetes of the young (disease) caused by mutation in GCKMODY 2 monogenic diabetes type 2MODY, type IIMODY2