manganese poisoning
Findings
No curated finding names manganese poisoning yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Manganese poisoning is associated with chronic inhalation of manganese particles by individuals who work with manganese ore. Clinical features include confusion; hallucinations; and an extrapyramidal syndrome (Parkinson disease, secondary) that includes rigidity; dystonia; retropulsion; and tremor. (Adams, Principles of Neurology, 6th ed, p1213)
Definition from the Mondo Disease Ontology (MONDO:0017638), read 2026-09-29. CC BY 4.0.
Features
30 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormal globus pallidus morphologyHPOHP:0002453
- Very frequent (80% to 99% of cases)
- Abnormality of extrapyramidal motor functionHPOHP:0002071
- Very frequent (80% to 99% of cases)
- Abnormality of mitochondrial metabolismHPOHP:0003287
- Very frequent (80% to 99% of cases)
- BradykinesiaHPOHP:0002067
- Very frequent (80% to 99% of cases)
- Cogwheel rigidityHPOHP:0002396
- Very frequent (80% to 99% of cases)
- DystoniaHPOHP:0001332
- Very frequent (80% to 99% of cases)
- Emotional labilityHPOHP:0000712
- Very frequent (80% to 99% of cases)
- Gait disturbanceHPOHP:0001288
- Very frequent (80% to 99% of cases)
- HeadacheHPOHP:0002315
- Very frequent (80% to 99% of cases)
- HypertoniaHPOHP:0001276
- Very frequent (80% to 99% of cases)
- Increased reactive oxygen species productionHPOHP:0025464
- Very frequent (80% to 99% of cases)
- Memory impairmentHPOHP:0002354
- Very frequent (80% to 99% of cases)
Show the remaining 18
- Postural instabilityHPOHP:0002172
- Very frequent (80% to 99% of cases)
- Postural tremorHPOHP:0002174
- Very frequent (80% to 99% of cases)
- Sleep-wake cycle disturbanceHPOHP:0006979
- Very frequent (80% to 99% of cases)
- Aggressive behaviorHPOHP:0000718
- Frequent (30% to 79% of cases)
- AkinesiaHPOHP:0002304
- Frequent (30% to 79% of cases)
- Compulsive behaviorsHPOHP:0000722
- Frequent (30% to 79% of cases)
Where it sits
- A kind of
Other names
2 names
Resolves to: manganese poisoning
- Also called
- manganese intoxicationManganism