malignant hyperthermia of anesthesia
Findings
No curated finding names malignant hyperthermia of anesthesia yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A pharmacogenetic disorder of skeletal muscle that presents as a hypermetabolic response to potent volatile anesthetic gasses such as halothane, sevoflurane, desflurane and the depolarizing muscle relaxant succinylcholine, and rarely, to stresses such as vigorous exercise and heat.
Definition from the Mondo Disease Ontology (MONDO:0018493), read 2026-09-29. CC BY 4.0.
Features
23 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Cardiomyocyte mitochondrial proliferationHPOHP:0031320
- Frequent (30% to 79% of cases)
- FeverHPOHP:0001945
- Frequent (30% to 79% of cases)
- HypercapniaHPOHP:0012416
- Frequent (30% to 79% of cases)
- HyperphosphatemiaHPOHP:0002905
- Frequent (30% to 79% of cases)
- Intermittent painful muscle spasmsHPOHP:0011964
- Frequent (30% to 79% of cases)
- Malignant hyperthermiaHPO · MondoHP:0002047
- Frequent (30% to 79% of cases)
- Metabolic acidosisHPOHP:0001942
- Frequent (30% to 79% of cases)
- Muscle stiffnessHPOHP:0003552
- Frequent (30% to 79% of cases)
- Supraventricular tachycardiaHPOHP:0004755
- Frequent (30% to 79% of cases)
- TachypneaHPOHP:0002789
- Frequent (30% to 79% of cases)
- Ventricular tachycardiaHPOHP:0004756
- Frequent (30% to 79% of cases)
- Abnormality of masseter muscleHPOHP:3000005
- Occasional (5% to 29% of cases)
Show the remaining 11
- Abnormality of the coagulation cascadeHPOHP:0003256
- Occasional (5% to 29% of cases)
- Acute hepatic failureHPOHP:0006554
- Occasional (5% to 29% of cases)
- Acute kidney injuryHPOHP:0001919
- Occasional (5% to 29% of cases)
- Acute rhabdomyolysisHPOHP:0008942
- Occasional (5% to 29% of cases)
- Elevated creatine kinase after exerciseHPOHP:0008331
- Occasional (5% to 29% of cases)
- Exercise-induced rhabdomyolysisHPOHP:0009045
- Occasional (5% to 29% of cases)
Genes
2 genes
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
Where it sits
Other names
7 names
Resolves to: malignant hyperthermia of anesthesia
- Also called
- anaesthesia related hyperthermiahyperthermia of anaesthesiahyperthermia of anesthesiamalignant hyperpyrexiamalignant hyperpyrexia due to anaesthesiamalignant hyperthermiamalignant hyperthermia syndrome