male infertility due to globozoospermia
Findings
No curated finding names male infertility due to globozoospermia yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A male infertility due to sperm disorder characterized by the presence, in sperm, of a large majority of round-headed spermatozoa that lack the acrosome and have an aberrant nuclear membrane and midpiece defects. The acrosomeless spermatozoa is not able to penetrate the zona pellucida following intercourse or IVF thus fertilization fails. Fertilization efficiency is also very low following intracytoplasmic spem injection due to the absence of the oocyte activation factor protein PLCzeta.
Definition from the Mondo Disease Ontology (MONDO:0015746), read 2026-09-29. CC BY 4.0.
Genes
3 genes
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
Where it sits
- Narrower terms (2)
Other names
2 names
Resolves to: male infertility due to globozoospermia
- Also called
- Male infertility due to round-headed spermatozoaround-headed sperm syndrome