long QT syndrome 15
MONDO:0014550Mondo
Findings
No curated finding names long QT syndrome 15 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Any long QT syndrome in which the cause of the disease is a mutation in the CALM2 gene.
Definition from the Mondo Disease Ontology (MONDO:0014550), read 2026-09-29. CC BY 4.0.
- Inheritance
- Autosomal dominant inheritance
- Onset and course
- Juvenile onset · Neonatal onset · Fetal onset · Childhood onset
HPO, annotations 2026-09-02
Features
12 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- 2:1 atrioventricular blockHPOHP:0034305
- 1 of 1 reported patient
- Prolonged QTc intervalHPOHP:0005184
- 6 of 6 reported patients
- Sinus bradycardiaHPOHP:0001688
- 1 of 1 reported patient
- SyncopeHPOHP:0001279
- 4 of 5 reported patients
- BradycardiaHPOHP:0001662
- 4 of 6 reported patients
- Cardiac arrestHPOHP:0001695
- 3 of 6 reported patients
- Premature ventricular contractionHPOHP:0006682
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- HGNC:1445HGNC:1445
- Definitive · G2P · Autosomal dominant · 2024
- Strong · Labcorp Genetics (formerly Invitae) · Autosomal dominant · 2021
Where it sits
- A kind of
Other names
4 names
Resolves to: long QT syndrome 15
- Also called
- CALM2 long QT syndromelong QT syndrome caused by mutation in CALM2long QT syndrome type 15LQT15