Loeffler endocarditis
Findings
No curated finding names Loeffler endocarditis yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Loeffler's endocarditis is a rare restrictive cardiomyopathy characterized by hypereosinophilia and fibrous thickening of the endocardium, with usually large thrombi against the ventricle walls, that can lead to cardiovascular complications such as heart failure and thromboembolism. It manifests with symptoms like edema, fatigue and shortness of breath. It is usually secondary to eosinophil-associated tissue damage and is associated with idiopathic hypereosinophilic syndrome, chronic eosinophilic leukemia, carcinoma, or lymphoma.
Definition from the Mondo Disease Ontology (MONDO:0019159), read 2026-09-29. CC BY 4.0.
Features
27 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormal thrombosisHPOHP:0001977
- Very frequent (80% to 99% of cases)
- Increased total eosinophil countHPOHP:0001880
- Very frequent (80% to 99% of cases)
- Myocardial eosinophilic infiltrationHPOHP:0031323
- Very frequent (80% to 99% of cases)
- Restrictive cardiomyopathyHPOHP:0001723
- Very frequent (80% to 99% of cases)
- Abnormal cardiomyocyte morphologyHPOHP:0031331
- Frequent (30% to 79% of cases)
- Abnormal heart valve morphologyHPOHP:0001654
- Frequent (30% to 79% of cases)
Show the remaining 15
- PalpitationsHPOHP:0001962
- Frequent (30% to 79% of cases)
- Weight lossHPOHP:0001824
- Frequent (30% to 79% of cases)
- Abnormal morphology of the chordae tendinae of the mitral valveHPOHP:0025523
- Occasional (5% to 29% of cases)
- Abnormal tricuspid chordae tendinae morphologyHPOHP:0031442
- Occasional (5% to 29% of cases)
- ArrhythmiaHPOHP:0011675
- Occasional (5% to 29% of cases)
- Complete right bundle branch blockHPOHP:0011712
- Occasional (5% to 29% of cases)
Where it sits
Other names
2 names
Resolves to: Loeffler endocarditis
- Also called
- eosinophilic endocarditiseosinophilic endomyocardial disease