locked-in syndrome
MONDO:0016567Mondo
Findings
No curated finding names locked-in syndrome yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Locked-in syndrome (LIS) is a neurological condition characterized by the presence of sustained eye opening, quadriplegia or quadriparesis, anarthria, preserved cognitive functioning and a primary code of communication that uses vertical eye movements or blinking.
Definition from the Mondo Disease Ontology (MONDO:0016567), read 2026-09-29. CC BY 4.0.
Features
16 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormality of the eyeHPOHP:0000478
- Very frequent (80% to 99% of cases)
- Abnormality of the voiceHPOHP:0001608
- Very frequent (80% to 99% of cases)
- Abnormality of visionHPOHP:0000504
- Very frequent (80% to 99% of cases)
- AnarthriaHPOHP:0002425
- Very frequent (80% to 99% of cases)
- Atypical behaviorHPOHP:0000708
- Very frequent (80% to 99% of cases)
- Cerebral palsyHPOHP:0100021
- Very frequent (80% to 99% of cases)
- DiplopiaHPOHP:0000651
- Very frequent (80% to 99% of cases)
- HypertoniaHPOHP:0001276
- Very frequent (80% to 99% of cases)
- Respiratory insufficiencyHPOHP:0002093
- Very frequent (80% to 99% of cases)
- SpasticityHPOHP:0001257
- Very frequent (80% to 99% of cases)
- TetraparesisHPOHP:0002273
- Very frequent (80% to 99% of cases)
- TetraplegiaHPOHP:0002445
- Very frequent (80% to 99% of cases)
Show the remaining 4
- Excessive salivationHPOHP:0003781
- Frequent (30% to 79% of cases)
- Feeding difficultiesHPOHP:0011968
- Frequent (30% to 79% of cases)
- Recurrent respiratory infectionsHPOHP:0002205
- Frequent (30% to 79% of cases)
- Hearing impairmentHPOHP:0000365
- Occasional (5% to 29% of cases)
Where it sits
- A kind of
Other names
3 names
Resolves to: locked-in syndrome
- Also called
- Cerebromedullospinal disconnectionLocked In Syndromelocked-in state