lobar holoprosencephaly
MONDO:0019756Mondo
Findings
No curated finding names lobar holoprosencephaly yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Lobar holoprosencephaly is the mildest classical form of holoprosencephaly (HPE) characterized by separation of the right and left cerebral hemispheres and lateral ventricules with some continuity across the frontal neocortex, especially rostrally and ventrally.
Definition from the Mondo Disease Ontology (MONDO:0019756), read 2026-09-29. CC BY 4.0.
Features
72 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Feeding difficultiesHPOHP:0011968
- Very frequent (80% to 99% of cases)
- HypotelorismHPOHP:0000601
- Very frequent (80% to 99% of cases)
- Abnormal central motor functionHPOHP:0011442
- Frequent (30% to 79% of cases)
- Abnormal hypothalamus physiologyHPOHP:0012285
- Frequent (30% to 79% of cases)
- Abnormality of the autonomic nervous systemHPOHP:0002270
- Frequent (30% to 79% of cases)
- Abnormality of the endocrine systemHPOHP:0000818
- Frequent (30% to 79% of cases)
- Abnormality of the eyeHPOHP:0000478
- Frequent (30% to 79% of cases)
- AnxietyHPOHP:0000739
- Frequent (30% to 79% of cases)
- Aspiration pneumoniaHPOHP:0011951
- Frequent (30% to 79% of cases)
- Attention deficit hyperactivity disorderHPOHP:0007018
- Frequent (30% to 79% of cases)
- Atypical behaviorHPOHP:0000708
- Frequent (30% to 79% of cases)
- Chronic lung diseaseHPOHP:0006528
- Frequent (30% to 79% of cases)
Show the remaining 60
- Cleft palateHPOHP:0000175
- Frequent (30% to 79% of cases)
- ConstipationHPOHP:0002019
- Frequent (30% to 79% of cases)
- Depressed nasal ridgeHPOHP:0000457
- Frequent (30% to 79% of cases)
- DepressionHPOHP:0000716
- Frequent (30% to 79% of cases)
- Diabetes insipidusHPOHP:0000873
- Frequent (30% to 79% of cases)
- Failure to thriveHPOHP:0001508
- Frequent (30% to 79% of cases)
Where it sits
- A kind of
- Narrower terms (2)