leukocyte adhesion deficiency
MONDO:0017570Mondo
Findings
No curated finding names leukocyte adhesion deficiency yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Leukocyte adhesion deficiency (LAD) is a primary immunodeficiency characterized by defects in the leukocyte adhesion process, marked leukocytosis and recurrent infections.
Definition from the Mondo Disease Ontology (MONDO:0017570), read 2026-09-29. CC BY 4.0.
Features
52 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormal neutrophil physiologyHPOHP:0011990
- Very frequent (80% to 99% of cases)
- Impaired neutrophil chemotaxisHPOHP:0040238
- Very frequent (80% to 99% of cases)
- Recurrent bacterial infectionsHPOHP:0002718
- Very frequent (80% to 99% of cases)
- Bone marrow hypocellularityHPOHP:0005528
- Frequent (30% to 79% of cases)
- Delayed umbilical cord separationHPOHP:0032434
- Frequent (30% to 79% of cases)
- GingivitisHPOHP:0000230
- Frequent (30% to 79% of cases)
- Increased total leukocyte countHPOHP:0001974
- Frequent (30% to 79% of cases)
- Lymphocytic interstitial pneumoniaHPOHP:0006527
- Frequent (30% to 79% of cases)
- Neonatal omphalitisHPOHP:0032435
- Frequent (30% to 79% of cases)
- Otitis mediaHPOHP:0000388
- Frequent (30% to 79% of cases)
- PeritonitisHPOHP:0002586
- Frequent (30% to 79% of cases)
- PneumoniaHPOHP:0002090
- Frequent (30% to 79% of cases)
Show the remaining 40
- Recurrent aphthous stomatitisHPOHP:0011107
- Frequent (30% to 79% of cases)
- Recurrent fungal infectionsHPOHP:0002841
- Frequent (30% to 79% of cases)
- Recurrent oral thrushHPOHP:0009098
- Frequent (30% to 79% of cases)
- Recurrent skin infectionsHPOHP:0001581
- Frequent (30% to 79% of cases)
- Recurrent staphylococcal infectionsHPOHP:0007499
- Frequent (30% to 79% of cases)
- Recurrent urinary tract infectionsHPOHP:0000010
- Frequent (30% to 79% of cases)