laurin-Sandrow syndrome
Findings
No curated finding names laurin-Sandrow syndrome yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Laurin-Sandrow syndrome (LSS) is characterized by complete polysyndactyly of the hands, mirror feet and nose anomalies (hypoplasia of the nasal alae and short columella), often associated with ulnar and/or fibular duplication (and sometimes tibial agenesis). It has been described in less than 20 cases. Some cases with the same clinical signs but without nasal defects have also been reported, and may represent the same entity. The etiology of LSS is unknown. Different modes of inheritance have been suggested.
Definition from the Mondo Disease Ontology (MONDO:0007615), read 2026-09-29. CC BY 4.0.
Features
28 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormal metacarpal morphologyHPOHP:0005916
- Very frequent (80% to 99% of cases)
- Aplasia/Hypoplasia of the thumbHPOHP:0009601
- Very frequent (80% to 99% of cases)
- Finger syndactylyHPOHP:0006101
- Very frequent (80% to 99% of cases)
- Mirror image polydactylyHPOHP:0010689
- Very frequent (80% to 99% of cases)
- Preaxial foot polydactylyHPOHP:0001841
- Very frequent (80% to 99% of cases)
- Preaxial hand polydactylyHPOHP:0001177
- Very frequent (80% to 99% of cases)
Show the remaining 16
- Absent tibiaHPOHP:0009556
- Frequent (30% to 79% of cases)
- Depressed nasal ridgeHPOHP:0000457
- Frequent (30% to 79% of cases)
- Fibular duplicationHPOHP:0010503
- Frequent (30% to 79% of cases)
- Limb duplicationHPOHP:0100524
- Frequent (30% to 79% of cases)
- Limitation of joint mobilityHPOHP:0001376
- Frequent (30% to 79% of cases)
- Prominent noseHPOHP:0000448
- Frequent (30% to 79% of cases)
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- LMBR1HGNC:13243
- Strong · PanelApp Australia · Autosomal dominant · 2025
- Supportive · Orphanet · Autosomal dominant · 2021
Where it sits
Other names
2 names
Resolves to: laurin-Sandrow syndrome
- Also called
- mirror hands and feets-nasal defects syndromeSandrow syndrome