lattice corneal dystrophy type I
Findings
No curated finding names lattice corneal dystrophy type I yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Type I lattice corneal dystrophy (LCDI) is a frequent form of stromal corneal dystrophy characterized by a network of delicate interdigitating branching filamentous opacities within the cornea with progressive visual impairment and no systemic manifestations.
Definition from the Mondo Disease Ontology (MONDO:0007380), read 2026-09-29. CC BY 4.0.
Features
17 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormal cornea morphologyHPOHP:0000481
- Very frequent (80% to 99% of cases)
- Central opacification of the corneaHPOHP:0011493
- Very frequent (80% to 99% of cases)
- Corneal opacityHPOHP:0007957
- Very frequent (80% to 99% of cases)
- Corneal scarringHPOHP:0000559
- Very frequent (80% to 99% of cases)
- Lattice corneal dystrophyHPOHP:0001149
- Very frequent (80% to 99% of cases)
- Visual lossHPOHP:0000572
- Very frequent (80% to 99% of cases)
- AstigmatismHPOHP:0000483
- Frequent (30% to 79% of cases)
- Corneal stromal edemaHPOHP:0012040
- Frequent (30% to 79% of cases)
- Ocular painHPOHP:0200026
- Frequent (30% to 79% of cases)
- PhotophobiaHPOHP:0000613
- Frequent (30% to 79% of cases)
- Recurrent corneal erosionsHPOHP:0000495
- Frequent (30% to 79% of cases)
- Red eyeHPOHP:0025337
- Frequent (30% to 79% of cases)
Show the remaining 5
- Subepithelial corneal opacitiesHPOHP:0008039
- Frequent (30% to 79% of cases)
- Central posterior corneal opacityHPOHP:0008511
- Occasional (5% to 29% of cases)
- Decreased corneal sensationHPOHP:0012155
- Occasional (5% to 29% of cases)
- High myopiaHPOHP:0011003
- Occasional (5% to 29% of cases)
- Slow decrease in visual acuityHPOHP:0007924
- Occasional (5% to 29% of cases)
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- TGFBIHGNC:11771
- Definitive · G2P · Autosomal dominant · 2018
- Supportive · Orphanet · Autosomal dominant · 2021
Where it sits
Other names
5 names
Resolves to: lattice corneal dystrophy type I
- Also called
- Biber-Haab-Dimmer dystrophyclassic lattice corneal dystrophylattice corneal dystrophy type 1LCD1LCDI