late-onset isolated ACTH deficiency
Findings
No curated finding names late-onset isolated ACTH deficiency yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Late-onset isolated ACTH deficiency is a rare, acquired, pituitary hormone deficiency characterized by secondary adrenal insufficiency, with normal secretion of anterior pituitary hormones, except for ACTH. Patients present with weakness, fatigue, weight loss, anorexia, vomiting/nausea, hypoglycemia, and abnormally low serum ACTH and cortisol levels. Association with autoimmune disease such as Hashimoto's thyroiditis has been described.
Definition from the Mondo Disease Ontology (MONDO:0016042), read 2026-09-29. CC BY 4.0.
Features
40 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Adrenocorticotropic hormone deficiencyHPOHP:0011748
- Obligate (100% of cases)
- Adrenocorticotropin deficient adrenal insufficiencyHPOHP:0011735
- Obligate (100% of cases)
- Decreased circulating cortisol levelHPOHP:0008163
- Obligate (100% of cases)
- Abdominal painHPOHP:0002027
- Very frequent (80% to 99% of cases)
- AnorexiaHPOHP:0002039
- Very frequent (80% to 99% of cases)
- AutoimmunityHPOHP:0002960
- Very frequent (80% to 99% of cases)
- Constipation
Show the remaining 28
- LethargyHPOHP:0001254
- Very frequent (80% to 99% of cases)
- Muscle weaknessHPOHP:0001324
- Very frequent (80% to 99% of cases)
- Nausea and vomitingHPOHP:0002017
- Very frequent (80% to 99% of cases)
- Weight lossHPOHP:0001824
- Very frequent (80% to 99% of cases)
- Graves diseaseHPOHP:0100647
- Frequent (30% to 79% of cases)
- Hashimoto thyroiditisHPOHP:0000872
- Frequent (30% to 79% of cases)