late-onset familial hypoaldosteronism
Findings
No curated finding names late-onset familial hypoaldosteronism yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A rare form of familial hypoaldosteronism characterized by adult onset of subnormal plasma aldosterone with elevated plasma renin activity, hyperkalemia, metabolic acidosis, and hypotension. Signs and symptoms are typically mild, and affected individuals may be clinically asymptomatic and diagnosed only after biochemical screening.
Definition from the Mondo Disease Ontology (MONDO:0035321), read 2026-09-29. CC BY 4.0.
Features
13 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormal circulating corticosterone levelHPOHP:0012112
- Occasional (5% to 29% of cases)
- Decreased circulating aldosterone concentrationHPOHP:0004319
- Occasional (5% to 29% of cases)
- Elevated serum 11-deoxycortisolHPOHP:0025436
- Occasional (5% to 29% of cases)
- FeverHPOHP:0001945
- Occasional (5% to 29% of cases)
- HyperkalemiaHPOHP:0002153
- Occasional (5% to 29% of cases)
- HyponatremiaHPOHP:0002902
- Occasional (5% to 29% of cases)
- Hypotension
Reported absent (1)
- Abnormal external genitalia morphologyHPOHP:0000811
Show the remaining 1
- Postnatal growth retardationHPOHP:0008897
- Very rare (1% to 4% of cases)
Where it sits
- A kind of
Other names
2 names
Resolves to: late-onset familial hypoaldosteronism
- Also called
- Late-onset familial hyperreninemic hypoaldosteronismMild aldosterone synthase deficiency