Lambert-Eaton myasthenic syndrome
MONDO:0018556Mondo
Findings
No curated finding names Lambert-Eaton myasthenic syndrome yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune, presynaptic disorder of neuromuscular transmission characterized by fluctuating muscle weakness and autonomic dysfunction frequently associated with small-cell lung cancer (SCLC).
Definition from the Mondo Disease Ontology (MONDO:0018556), read 2026-09-29. CC BY 4.0.
Features
16 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormal autonomic nervous system physiologyHPOHP:0012332
- Very frequent (80% to 99% of cases)
- Calcium channel antibody positivityHPOHP:0030209
- Very frequent (80% to 99% of cases)
- Diminished deep tendon reflexHPOHP:0001315
- Very frequent (80% to 99% of cases)
- EMG: decremental response of compound muscle action potential to repetitive nerve stimulationHPOHP:0003403
- Very frequent (80% to 99% of cases)
- EMG: repetitive nerve stimulation abnormalityHPOHP:0030000
- Very frequent (80% to 99% of cases)
- Progressive proximal muscle weaknessHPOHP:0009073
- Very frequent (80% to 99% of cases)
- XerostomiaHPOHP:0000217
- Very frequent (80% to 99% of cases)
- Abnormality of the orbital regionHPOHP:0000315
- Frequent (30% to 79% of cases)
- Anti-P/Q-type VGCC antibody positivityHPOHP:5000027
- Frequent (30% to 79% of cases)
- Bulbar signsHPOHP:0002483
- Frequent (30% to 79% of cases)
- ConstipationHPOHP:0002019
- Frequent (30% to 79% of cases)
- ImpotenceHPOHP:0000802
- Frequent (30% to 79% of cases)
Show the remaining 4
- Small cell lung carcinomaHPOHP:0030357
- Frequent (30% to 79% of cases)
- HypohidrosisHPOHP:0000966
- Occasional (5% to 29% of cases)
- Keratoconjunctivitis siccaHPOHP:0001097
- Occasional (5% to 29% of cases)
- Orthostatic hypotension due to autonomic dysfunctionHPOHP:0004926
- Occasional (5% to 29% of cases)
Where it sits
- A kind of
Other names
7 names
Resolves to: Lambert-Eaton myasthenic syndrome
- Also called
- Eaton Lambert syndromeEaton-Lambert syndromeLambert Eaton myasthenic syndromeLambert Eaton syndromeLambert-Eaton syndromemyasthenic syndrome of Lambert-Eatonmyasthenic-myopathic syndrome of Lambert-Eaton