Kleine-Levin syndrome
MONDO:0007863Mondo
Findings
No curated finding names Kleine-Levin syndrome yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Kleine-Levin syndrome (KLS) is a rare neurological disorder of unknown origin characterized by relapsing-remitting episodes of hypersomnia in association with cognitive and behavioral disturbances.
Definition from the Mondo Disease Ontology (MONDO:0007863), read 2026-09-29. CC BY 4.0.
Features
35 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Cognitive impairmentHPOHP:0100543
- Very frequent (80% to 99% of cases)
- ConfusionHPOHP:0001289
- Very frequent (80% to 99% of cases)
- Episodic hypersomniaHPOHP:0007200
- Very frequent (80% to 99% of cases)
- Abnormal brain FDG positron emission tomographyHPOHP:0012658
- Frequent (30% to 79% of cases)
- Abnormal eating behaviorHPOHP:0100738
- Frequent (30% to 79% of cases)
- Abnormal speech patternHPOHP:0002167
- Frequent (30% to 79% of cases)
- AgitationHPOHP:0000713
- Frequent (30% to 79% of cases)
- Amplification of sexual behaviorHPOHP:5200321
- Frequent (30% to 79% of cases)
- AnxietyHPOHP:0000739
- Frequent (30% to 79% of cases)
- ApathyHPOHP:0000741
- Frequent (30% to 79% of cases)
- DepressionHPOHP:0000716
- Frequent (30% to 79% of cases)
- FeverHPOHP:0001945
- Frequent (30% to 79% of cases)
Show the remaining 23
- HeadacheHPOHP:0002315
- Frequent (30% to 79% of cases)
- HyperhidrosisHPOHP:0000975
- Frequent (30% to 79% of cases)
- IrritabilityHPOHP:0000737
- Frequent (30% to 79% of cases)
- ParageusiaHPOHP:0031249
- Frequent (30% to 79% of cases)
- ParosmiaHPOHP:0034004
- Frequent (30% to 79% of cases)
- PhotophobiaHPOHP:0000613
- Frequent (30% to 79% of cases)