KID syndrome
Findings
No curated finding names KID syndrome yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Keratitis (and hystrix-like) ichthyosis deafness (KID/HID) syndrome is a rare congenital ectodermal disorder characterized by vascularizing keratitis, hyperkeratotic skin lesions and hearing loss.
Definition from the Mondo Disease Ontology (MONDO:0018781), read 2026-09-29. CC BY 4.0.
Features
60 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Corneal neovascularizationHPOHP:0011496
- Very frequent (80% to 99% of cases)
- Abnormality of the dentitionHPOHP:0000164
- Frequent (30% to 79% of cases)
- Congenital ichthyosiform erythrodermaHPOHP:0007431
- Frequent (30% to 79% of cases)
- ConjunctivitisHPOHP:0000509
- Frequent (30% to 79% of cases)
- Corneal erosionHPOHP:0200020
- Frequent (30% to 79% of cases)
- Epidermal acanthosisHPOHP:0025092
- Frequent (30% to 79% of cases)
- Follicular hyperkeratosisHPOHP:0007502
- Frequent (30% to 79% of cases)
- KeratitisHPOHP:0000491
- Frequent (30% to 79% of cases)
- Keratoconjunctivitis siccaHPOHP:0001097
- Frequent (30% to 79% of cases)
- Limbal stem cell deficiencyHPOHP:0032107
- Frequent (30% to 79% of cases)
- Nail dystrophyHPOHP:0008404
- Frequent (30% to 79% of cases)
- Palmoplantar keratodermaHPOHP:0000982
- Frequent (30% to 79% of cases)
Show the remaining 48
- PhotophobiaHPOHP:0000613
- Frequent (30% to 79% of cases)
- Prelingual sensorineural hearing impairmentHPOHP:0000399
- Frequent (30% to 79% of cases)
- Progeroid facial appearanceHPOHP:0005328
- Frequent (30% to 79% of cases)
- Punctate keratitisHPOHP:0011859
- Frequent (30% to 79% of cases)
- Recurrent skin infectionsHPOHP:0001581
- Frequent (30% to 79% of cases)
- Scaling skinHPOHP:0040189
- Frequent (30% to 79% of cases)
Genes
2 genes
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
Where it sits
Other names
5 names
Resolves to: KID syndrome
- Also called
- ichthyosis hystrix Rheydt typeKeratitis Ichthyosis Deafness Syndromekeratitis-ichthyosis-deafness/Hystrix-like ichthyosis-deafness syndromeKID/HID syndromeSenter syndrome