isolated agammaglobulinemia
MONDO:0016462Mondo
Findings
No curated finding names isolated agammaglobulinemia yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Isolated agammaglobulinemia (IA) is the non-syndromic form of agammaglobulinemia, a primary immunodeficiency disease, and is characterized by deficient gamma globulins and associated predisposition to frequent and recurrent infections from infancy.
Definition from the Mondo Disease Ontology (MONDO:0016462), read 2026-09-29. CC BY 4.0.
Features
28 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormal lymphocyte morphologyHPOHP:0004332
- Very frequent (80% to 99% of cases)
- DiarrheaHPOHP:0002014
- Very frequent (80% to 99% of cases)
- Failure to thriveHPOHP:0001508
- Very frequent (80% to 99% of cases)
- FatigueHPOHP:0012378
- Very frequent (80% to 99% of cases)
- FeverHPOHP:0001945
- Very frequent (80% to 99% of cases)
- ImmunodeficiencyHPOHP:0002721
- Very frequent (80% to 99% of cases)
- Inflammatory abnormality of the eyeHPOHP:0100533
- Very frequent (80% to 99% of cases)
- Otitis mediaHPOHP:0000388
- Very frequent (80% to 99% of cases)
- Recurrent cutaneous abscess formationHPOHP:0100838
- Very frequent (80% to 99% of cases)
- Recurrent respiratory infectionsHPOHP:0002205
- Very frequent (80% to 99% of cases)
- SinusitisHPOHP:0000246
- Very frequent (80% to 99% of cases)
- Skin rashHPOHP:0000988
- Very frequent (80% to 99% of cases)
Show the remaining 16
- Skin ulcerHPOHP:0200042
- Very frequent (80% to 99% of cases)
- Abnormality of neutrophilsHPOHP:0001874
- Frequent (30% to 79% of cases)
- Abnormality of the lymphatic systemHPOHP:0100763
- Frequent (30% to 79% of cases)
- PneumoniaHPOHP:0002090
- Frequent (30% to 79% of cases)
- Abnormal facial shapeHPOHP:0001999
- Occasional (5% to 29% of cases)
- Abnormality of the tonsilsHPOHP:0100765
- Occasional (5% to 29% of cases)
Where it sits
- A kind of
- Narrower terms (2)
Other names
2 names
Resolves to: isolated agammaglobulinemia
- Also called
- isolated hypogammaglobulinemianonsyndromic agammaglobulinemia