iridocorneal endothelial syndrome
Findings
No curated finding names iridocorneal endothelial syndrome yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Iridocorneal endothelial (ICE) syndrome describes a group of progressive corneal proliferative endotheliopathies comprised of Chandler syndrome, Cogan-Reese syndrome and essential iris atrophy, affecting mainly young adult females and characterized by iris holes and atrophy, papillary distortion, anterior synechiae, corneal edema and often with secondary glaucoma and corneal decompensation as complications
Definition from the Mondo Disease Ontology (MONDO:0018988), read 2026-09-29. CC BY 4.0.
Features
16 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormal migration of corneal endotheliumHPOHP:0011489
- Frequent (30% to 79% of cases)
- Anterior synechiae of the anterior chamberHPOHP:0011483
- Frequent (30% to 79% of cases)
- Corneal stromal edemaHPOHP:0012040
- Frequent (30% to 79% of cases)
- Ectopia pupillaeHPOHP:0009918
- Frequent (30% to 79% of cases)
- GlaucomaHPOHP:0000501
- Frequent (30% to 79% of cases)
- Iris atrophyHPOHP:0001089
- Frequent (30% to 79% of cases)
- Progressive visual loss
Show the remaining 4
- PolycoriaHPOHP:0011500
- Occasional (5% to 29% of cases)
- Posterior synechiae of the anterior chamberHPOHP:0011484
- Occasional (5% to 29% of cases)
- Uveal ectropionHPOHP:0025358
- Occasional (5% to 29% of cases)
- Heterochromia iridisHPOHP:0001100
- Very rare (1% to 4% of cases)
Where it sits
- A kind of
- Narrower terms (3)
Other names
1 name
Resolves to: iridocorneal endothelial syndrome
- Also called
- ICE syndrome