intrahepatic cholestasis of pregnancy
MONDO:0100429Mondo
Findings
No curated finding names intrahepatic cholestasis of pregnancy yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A cholestatic disorder characterized by (i) pruritus with onset in the second or third trimester of pregnancy, (ii) elevated serum aminotransferases and bile acid levels, and (iii) spontaneous relief of signs and symptoms within two to three weeks after delivery.
Definition from the Mondo Disease Ontology (MONDO:0100429), read 2026-09-29. CC BY 4.0.
Features
24 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Increased serum bile acid concentrationHPOHP:0012202
- Very frequent (80% to 99% of cases)
- PruritusHPOHP:0000989
- Very frequent (80% to 99% of cases)
- Abnormality of the digestive systemHPOHP:0025031
- Frequent (30% to 79% of cases)
- Elevated circulating hepatic transaminase concentrationHPOHP:0002910
- Frequent (30% to 79% of cases)
- InsomniaHPOHP:0100785
- Frequent (30% to 79% of cases)
- Abnormal circulating interleukin concentrationHPOHP:0011117
- Occasional (5% to 29% of cases)
- Abnormal pineal melatonin secretionHPOHP:0012689
- Occasional (5% to 29% of cases)
- DepressionHPOHP:0000716
- Occasional (5% to 29% of cases)
- Elevated circulating alkaline phosphatase concentrationHPOHP:0003155
- Occasional (5% to 29% of cases)
- HyperbilirubinemiaHPOHP:0002904
- Occasional (5% to 29% of cases)
- Meconium stained amniotic fluidHPOHP:0012420
- Occasional (5% to 29% of cases)
- Neonatal respiratory distressHPOHP:0002643
- Occasional (5% to 29% of cases)
Reported absent (2)
- AutoimmunityHPOHP:0002960
- Skin rashHPOHP:0000988
Show the remaining 12
- Palmar pruritusHPOHP:0031248
- Occasional (5% to 29% of cases)
- Pruritus on footHPOHP:0030900
- Occasional (5% to 29% of cases)
- Abdominal painHPOHP:0002027
- Very rare (1% to 4% of cases)
- Abnormality of the pancreasHPOHP:0001732
- Very rare (1% to 4% of cases)
- AscitesHPOHP:0001541
- Very rare (1% to 4% of cases)
- AsterixisHPOHP:0012164
- Very rare (1% to 4% of cases)
Where it sits
- A kind of
Other names
4 names
Resolves to: intrahepatic cholestasis of pregnancy
- Also called
- gravidic intrahepatic cholestasispregnancy related cholestasispregnancy-related cholestasisrecurrent intrahepatic cholestasis of pregnancy