intellectual disability, X-linked 90
Findings
No curated finding names intellectual disability, X-linked 90 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Any non-syndromic X-linked intellectual disability in which the cause of the disease is a mutation in the DLG3 gene.
Definition from the Mondo Disease Ontology (MONDO:0010452), read 2026-09-29. CC BY 4.0.
- Inheritance
- X-linked inheritance · X-linked recessive inheritance
HPO, annotations 2026-09-02
Features
14 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Delayed speech and language developmentHPOHP:0000750
- 7 of 7 reported patients
- Intellectual disabilityHPOHP:0001249
- 18 of 18 reported patients
- Motor delayHPOHP:0001270
- 6 of 6 reported patients
- Attention deficit hyperactivity disorderHPOHP:0007018
- 3 of 6 reported patients
- EnuresisHPOHP:0000805
- 4 of 8 reported patients
- High palateHPOHP:0000218
- 3 of 8 reported patients
- HypotoniaHPOHP:0001252
Show the remaining 2
- SeizureHPOHP:0001250
- 1 of 8 reported patients
- Global developmental delayHPOHP:0001263
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- DLG3HGNC:2902
- Definitive · G2P · X-linked · 2015
- Strong · Labcorp Genetics (formerly Invitae) · X-linked · 2021
- Strong · PanelApp Australia · X-linked · 2025
Where it sits
Other names
5 names
Resolves to: intellectual disability, X-linked 90
- Also called
- DLG3 non-syndromic X-linked intellectual disabilityintellectual developmental disorder, X-linked 90, X-linked recessiveintellectual disability, X-linked type 90mental retardation, X-linked type 90non-syndromic X-linked intellectual disability caused by mutation in DLG3