intellectual disability, X-linked 61
Findings
No curated finding names intellectual disability, X-linked 61 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Any non-syndromic X-linked intellectual disability in which the cause of the disease is a mutation in the RLIM gene.
Definition from the Mondo Disease Ontology (MONDO:0010506), read 2026-09-29. CC BY 4.0.
- Inheritance
- X-linked recessive inheritance
- Onset and course
- Infantile onset
HPO, annotations 2026-09-02
Features
12 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Broad foreheadHPOHP:0000337
- 3 of 3 reported patients
- Delayed speech and language developmentHPOHP:0000750
- 3 of 3 reported patients
- Intellectual disabilityHPOHP:0001249
- 4 of 4 reported patients · Male
- Autistic behaviorHPOHP:0000729
- 3 of 4 reported patients
- Feeding difficultiesHPOHP:0011968
- 2 of 3 reported patients
- Fine hairHPOHP:0002213
- 2 of 3 reported patients
- HypertelorismHPOHP:0000316
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- RLIMHGNC:13429
- Strong · Labcorp Genetics (formerly Invitae) · X-linked · 2021
- Strong · G2P · X-linked · 2025
- Strong · Broad Center for Mendelian Genomics · X-linked · 2020
- Strong · PanelApp Australia · X-linked · 2025
- Moderate · Ambry Genetics · X-linked · 2020
Where it sits
Other names
7 names
Resolves to: intellectual disability, X-linked 61
- Also called
- intellectual disability, X-linked type 61mental retardation, X-linked 61mental retardation, X-linked type 61MRX61non-syndromic X-linked intellectual disability caused by mutation in RLIMRLIM non-syndromic X-linked intellectual disabilityTonne-Kalscheuer syndrome