insulin autoimmune syndrome
Findings
No curated finding names insulin autoimmune syndrome yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Insulin autoimmune syndrome is a rare condition that causes low blood sugar (hypoglycemia). This occurs because the body begins to make a specific kind of protein called antibodies to attack insulin. Insulin is a naturally occurring hormone that is responsible for keeping blood sugar at a normal level. When blood sugar levels get too high, insulin helps to store the sugar for future use. People affected by insulin autoimmune syndrome have antibodies that attack insulin, causing it to work too hard and the level of blood sugar to become too low. Insulin autoimmune syndrome most often begins during adulthood.
Definition from the Mondo Disease Ontology (MONDO:0018465), read 2026-09-29. CC BY 4.0.
Features
13 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Hyperinsulinemic hypoglycemiaHPOHP:0000825
- Obligate (100% of cases)
- Autoimmune antibody positivityHPOHP:0030057
- Very frequent (80% to 99% of cases)
- Increased circulating immunoglobulin concentrationHPOHP:0010702
- Very frequent (80% to 99% of cases)
- Insulin resistanceHPOHP:0000855
- Very frequent (80% to 99% of cases)
- Insulin-resistant diabetes mellitusHPOHP:0000831
- Very frequent (80% to 99% of cases)
- Systemic lupus erythematosusHPOHP:0002725
- Very frequent (80% to 99% of cases)
Show the remaining 1
- Weight lossHPOHP:0001824
- Frequent (30% to 79% of cases)
Where it sits
Other names
1 name
Resolves to: insulin autoimmune syndrome
- Also called
- Hirata disease