immunodeficiency due to selective anti-polysaccharide antibody deficiency
MONDO:0019093Mondo
Findings
No curated finding names immunodeficiency due to selective anti-polysaccharide antibody deficiency yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Immunodeficiency due to selective anti-polysaccharide antibody deficiency is characterized by normal immunoglobulin levels (including IgG sub-classes) but impaired polysaccharide responsiveness (IPR).
Definition from the Mondo Disease Ontology (MONDO:0019093), read 2026-09-29. CC BY 4.0.
Features
15 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Complete or near-complete absence of specific antibody response to protein-conjugated Haemophilus influenzae type b vaccineHPOHP:0410303
- Very frequent (80% to 99% of cases)
- Complete or near-complete absence of specific antibody response to unconjugated pneumococcus polysaccharideHPOHP:0410300
- Very frequent (80% to 99% of cases)
- Decreased specific anti-polysaccharide antibody concentrationHPOHP:0002848
- Very frequent (80% to 99% of cases)
- Decreased specific antibody response to protein-conjugated polysaccharide vaccineHPOHP:0410302
- Very frequent (80% to 99% of cases)
- Decreased specific antibody response to unconjugated polysaccharide vaccineHPOHP:0410299
- Very frequent (80% to 99% of cases)
- Decreased memory B cell proportionHPOHP:0030374
- Frequent (30% to 79% of cases)
- Otitis mediaHPOHP:0000388
- Frequent (30% to 79% of cases)
- Recurrent bacterial upper respiratory tract infectionsHPOHP:0031949
- Frequent (30% to 79% of cases)
- Recurrent upper and lower respiratory tract infectionsHPOHP:0200117
- Frequent (30% to 79% of cases)
- RhinitisHPOHP:0012384
- Frequent (30% to 79% of cases)
- SinusitisHPOHP:0000246
- Frequent (30% to 79% of cases)
- AsthmaHPOHP:0002099
- Occasional (5% to 29% of cases)
Reported absent (4)
- Abnormal circulating IgA concentrationHPOHP:0410240
- Abnormal circulating IgG concentrationHPOHP:0410242
- Abnormal circulating IgM concentrationHPOHP:0410243
- Complete or near-complete absence of specific antibody response to tetanus vaccineHPOHP:0410295
Show the remaining 3
- Atopic dermatitisHPOHP:0001047
- Occasional (5% to 29% of cases)
- Decreased total B cell countHPOHP:0010976
- Occasional (5% to 29% of cases)
- Recurrent bacterial meningitisHPOHP:0007274
- Occasional (5% to 29% of cases)
Where it sits
- A kind of