IgG4-related thyroid disease
Findings
No curated finding names IgG4-related thyroid disease yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Riedel thyroiditis is a fibroinflammatory disorder of the thyroid gland, occurring more frequently in females, characterized a large, hard thyroid mass, and presenting with pressure symptoms (breathing difficulB,ties and dysphagia) or voice hoarseness and aphonia (impingement of recurrent laryngeal nerve). It can often be associated with extracervical fibroinflammatory disorders such as retroperitoneal fibrosis, primary scleroisng cholangitis and autoimmune diseases such as Hashimoto struma, Addison disease, and Biermer disease.
Definition from the Mondo Disease Ontology (MONDO:0018992), read 2026-09-29. CC BY 4.0.
Features
23 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- GoiterHPOHP:0000853
- Very frequent (80% to 99% of cases)
- ThyroiditisHPOHP:0100646
- Very frequent (80% to 99% of cases)
- Anti-thyroglobulin antibody positivityHPOHP:0032069
- Frequent (30% to 79% of cases)
- Anti-thyroid peroxidase antibody positivityHPOHP:0025379
- Frequent (30% to 79% of cases)
- Hashimoto thyroiditisHPOHP:0000872
- Frequent (30% to 79% of cases)
- HypothyroidismHPOHP:0000821
- Frequent (30% to 79% of cases)
- Increased circulating IgG4 concentration
Show the remaining 11
- Nodular goiterHPOHP:0005994
- Occasional (5% to 29% of cases)
- Tracheal stenosisHPOHP:0002777
- Occasional (5% to 29% of cases)
- Vocal cord paralysisHPOHP:0001605
- Occasional (5% to 29% of cases)
- Abnormal mediastinum morphologyHPOHP:0045026
- Very rare (1% to 4% of cases)
- Abnormal pituitary gland morphologyHPOHP:0012503
- Very rare (1% to 4% of cases)
- Abnormality of the ocular adnexaHPOHP:0032039
- Very rare (1% to 4% of cases)
Where it sits
Other names
4 names
Resolves to: IgG4-related thyroid disease
- Also called
- Riedel diseaseRiedel fibrosing thyroiditisRiedel thyroiditisRiedel's fibrosing thyroiditis