IgG4-related submandibular gland disease
MONDO:0018674Mondo
Findings
No curated finding names IgG4-related submandibular gland disease yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A chronic fibrotic inflammatory process affecting the salivary gland. Signs and symptoms include firm and painful swelling of the salivary gland, often associated with the presence of salivary gland stones.
Definition from the Mondo Disease Ontology (MONDO:0018674), read 2026-09-29. CC BY 4.0.
Features
25 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormality of the submandibular glandsHPOHP:0010287
- Very frequent (80% to 99% of cases)
- AutoimmunityHPOHP:0002960
- Very frequent (80% to 99% of cases)
- Increased circulating IgG concentrationHPOHP:0003237
- Very frequent (80% to 99% of cases)
- Increased circulating IgG4 concentrationHPOHP:0032300
- Very frequent (80% to 99% of cases)
- Abnormal salivary gland morphologyHPOHP:0010286
- Frequent (30% to 79% of cases)
- Enlarged lacrimal glandsHPOHP:0007734
- Frequent (30% to 79% of cases)
- Increased circulating IgE concentrationHPOHP:0003212
- Frequent (30% to 79% of cases)
- Increased circulating immunoglobulin concentrationHPOHP:0010702
- Frequent (30% to 79% of cases)
- Increased total eosinophil countHPOHP:0001880
- Frequent (30% to 79% of cases)
- LymphadenopathyHPOHP:0002716
- Frequent (30% to 79% of cases)
- Reduced circulating complement concentrationHPOHP:0004431
- Frequent (30% to 79% of cases)
- SialadenitisHPOHP:0031281
- Frequent (30% to 79% of cases)
Show the remaining 13
- XerostomiaHPOHP:0000217
- Frequent (30% to 79% of cases)
- Abnormal pancreas morphologyHPOHP:0012090
- Occasional (5% to 29% of cases)
- Abnormality of the kidneyHPOHP:0000077
- Occasional (5% to 29% of cases)
- Abnormality of the thyroid glandHPOHP:0000820
- Occasional (5% to 29% of cases)
- Enlargement of parotid glandHPOHP:0011801
- Occasional (5% to 29% of cases)
- Facial edemaHPOHP:0000282
- Occasional (5% to 29% of cases)
Where it sits
Other names
8 names
Resolves to: IgG4-related submandibular gland disease
- Also called
- chronic sclerosing sialadenitisIgG4-related sialadenitisKuttner tumorKüttner tumorKuttner tumourKüttner tumourKuttner's tumorKuttner's tumour