IgE responsiveness, atopic
Findings
No curated finding names IgE responsiveness, atopic yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Immediate hypersensitivity reaction - type I reaction, involves immunoglobulin E (IgE)-mediated release of chemical mediators from mast cells and basophils. Th2 cells produce IL-4 and IL-13, which then act on B cells to promote the production of antigen-specific IgE. Reexposure to the antigen can then result in the antigen binding to and cross-linking the bound IgE antibodies on the mast cells and basophils. This causes the release of preformed mediators (histamine, tryptase, tryptase, chemotactic factors), newly synthesized mediators (leukotrienes, prostaglandin, thromboxane, platelet-activating factor, adenosine, bradykinin), and cytokines from these cells that results in structural and functional changes to the affected tissue.
Definition from the Mondo Disease Ontology (MONDO:0007817), read 2026-09-29. CC BY 4.0.
Genes
2 genes
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
Where it sits
Other names
7 names
Resolves to: IgE responsiveness, atopic
- Also called
- IgE, elevated level ofimmediate hypersensitivitytype 1 hypersensitivitytype 1 hypersensitivity reactiontype I hypersensitivitytype I hypersensitivity reactiontype I immediate hypersensitivity reaction