IgA nephropathy, susceptibility to, 3
Findings
No curated finding names IgA nephropathy, susceptibility to, 3 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Any IgA glomerulonephritis in which the cause of the disease is a mutation in the SPRY2 gene.
Definition from the Mondo Disease Ontology (MONDO:0014786), read 2026-09-29. CC BY 4.0.
- Inheritance
- Autosomal dominant inheritance
- Onset and course
- Young adult onset
HPO, annotations 2026-09-02
Features
6 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- HematuriaHPOHP:0000790
- 5 of 8 reported patients
- HypertensionHPOHP:0000822
- 3 of 10 reported patients
- Stage 5 chronic kidney diseaseHPOHP:0003774
- 2 of 11 reported patients
- ProteinuriaHPOHP:0000093
- 1 of 8 reported patients
- IgA deposition in the glomerulusHPOHP:0000794
- Mesangial hypercellularityHPOHP:0012574
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- SPRY2HGNC:11270
- Limited · Ambry Genetics · Autosomal dominant · 2018
- Limited · Labcorp Genetics (formerly Invitae) · Unknown · 2017
Where it sits
- A kind of
Other names
5 names
Resolves to: IgA nephropathy, susceptibility to, 3
- Also called
- IgA glomerulonephritis caused by mutation in SPRY2IgA nephropathy, susceptibility to, 3; IGAN3IgA nephropathy, susceptibility to, type 3IGAN3SPRY2 IgA glomerulonephritis