idiopathic hypercalciuria
Findings
No curated finding names idiopathic hypercalciuria yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A rare renal disease characterized by persistent excess urinary calcium excretion in the absence of an underlying systemic disease and hypercalcemia. The condition leads to an increased risk for the formation of kidney stones and nephrocalcinosis, as well as reduced bone mineral density with increased incidence of fractures in some patients.
Definition from the Mondo Disease Ontology (MONDO:0700418), read 2026-09-29. CC BY 4.0.
Features
5 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- HypercalciuriaHPOHP:0002150
- Obligate (100% of cases)
- Renal calcium wastingHPOHP:0012637
- Obligate (100% of cases)
- Calcium oxalate nephrolithiasisHPOHP:0008672
- Frequent (30% to 79% of cases)
- OsteopeniaHPOHP:0000938
- Frequent (30% to 79% of cases)
- OsteoporosisHPOHP:0000939
- Occasional (5% to 29% of cases)
Reported absent (2)
- Abnormal circulating calcium concentrationHPOHP:0004363
- Parathormone-independent increased renal tubular calcium reabsorptionHPOHP:0003529
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- ADCY10HGNC:21285
- Supportive · Orphanet · Autosomal dominant · 2021