hypotrichosis simplex of the scalp
Findings
No curated finding names hypotrichosis simplex of the scalp yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Hypotrichosis simplex of the scalp (HSS) is characterized by diffuse progressive hair loss that is confined to the scalp.
Definition from the Mondo Disease Ontology (MONDO:0019575), read 2026-09-29. CC BY 4.0.
Features
12 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Fine hairHPOHP:0002213
- Very frequent (80% to 99% of cases)
- Slow-growing scalp hairHPOHP:0100038
- Very frequent (80% to 99% of cases)
- Alopecia of scalpHPOHP:0002293
- Frequent (30% to 79% of cases)
- Epidermal acanthosisHPOHP:0025092
- Frequent (30% to 79% of cases)
- HyperkeratosisHPOHP:0000962
- Frequent (30% to 79% of cases)
- ParakeratosisHPOHP:0001036
- Frequent (30% to 79% of cases)
- Sparse scalp hairHPOHP:0002209
- Frequent (30% to 79% of cases)
- Allergic rhinitisHPOHP:0003193
- Occasional (5% to 29% of cases)
- Atopic dermatitisHPOHP:0001047
- Occasional (5% to 29% of cases)
- Increased circulating IgE concentrationHPOHP:0003212
- Occasional (5% to 29% of cases)
- PruritusHPOHP:0000989
- Occasional (5% to 29% of cases)
- Scaling skinHPOHP:0040189
- Occasional (5% to 29% of cases)
Reported absent (9)
- Abnormal eyebrow morphologyHPOHP:0000534
- Abnormal eyelash morphologyHPOHP:0000499
- Abnormal nail morphologyHPOHP:0001597
- Abnormality of the axillary hairHPOHP:0100134
- Abnormality of the dentitionHPOHP:0000164
- Abnormality of the pubic hairHPOHP:0100133
- Absent facial hairHPOHP:0002550
- Generalized hypotrichosisHPOHP:0004528
- Hypohidrosis or hyperhidrosis
Genes
2 genes
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
Where it sits
- A kind of
- Narrower terms (2)
Other names
1 name
Resolves to: hypotrichosis simplex of the scalp
- Also called
- hereditary hypotrichosis simplex of the scalp